• Efficacy Evaluation of a Chlorine Dioxide Containing Toothpaste (DioxiBrite?) on Plaque and Gingivitis

  L. Mueller-Joseph, State University of New York at Farmingdale, Dept. of Dental Hygiene, Farmingdale, NY

  A double blind study in 14 patients showed that DioxiBrite toothpaste was statistically significantly (p> 0.0482) better than Colgate's TOTAL® for plaque reduction, and as effective in treating gingivitis. These results are significant given that TOTAL has FDA approval for these indications.

• Efficacy Evaluation of a Chlorine Dioxide Toothpaste (DioxiBrite?) on Plaque and Gingivitis

  A double blind study in 55 patients confirmed the results of the previous study by demonstrating that DioxiBrite toothpaste was better than Colgate's TOTAL on plaque.

DioxiRinse? Mouthwash

• Effect of DioxiRinse? Mouthwash on Oral Malodor: Clinical and Microbiological Pilot Study

S. Nachnani, University Health Resources Group, Inc., Culver City, CA

A one-week study in 15 patients with halitosis demonstrated that DioxiRinse mouthwash effectively reduced oral malodor, volatile sulfur compounds, and microbial counts. Study subjects commented that they "liked the mouthwash".

BioClenz? Dental Line Cleaner

• Evaluation of DioxiClear? as a treatment for dental unit waterline biofilms and as a water contamination control agent

R. Puttaiah, Baylor College of Dentistry TAMUS HSC, Dallas, TX

• Utilization of two concentrations of ClO₂ Cleaner in controlling dental waterline contamination

Presented at the 30th Annual Meeting of the American Association for Dental Research, March 2001. Chicago, Ill. J Dent Research Vol. 80 Special Issue [AADR Abstracts]. Abstract # 1066.

R. Puttaiah, et al, Baylor College of Dentistry TAMUS HSC, Dallas, TX

In two studies, BioClenz (formerly named DioxiClear) Dental Line Cleaner proved effective as a decontaminant for dental lines in removing biofilm and bacteria, meeting ADA specifications. BioClenz was more effective, safer and less corrosive than concentrated bleach.

DioxiDent? Liquid

• Clinical and Microbiological Efficacy of Chlorine Dioxide (ClO2) in the Management of Chronic Atrophic Candidiasis

Submitted for Publication in the Journal of Prosthetic Dentistry

AR. Mohammad, The Ohio State University, College of Dentistry Columbus, Ohio

A 30 patient trial in which DioxiDent liquid proved outstanding for the treatment of Candida albicans yeast infections of the mouth.

Figure #1 - Group A			Figure #2 - Group A
BEFORE TREATMENT			AFTER TREATMENT
	Patient with severe chronic atrophic candidiasis (grade 3) and salivary count of 53,000 CFU/ml		. Same patient as in Figure #1 after 10 days of using mouth rinse 0.8% chlorine dioxide (grade 0) and salivary count of 400 CFU/ml

For more information on the above mentioned studies, contact Frontier at 800 767-3486 or vab@frontierpharm.com.